Doncaster will be without Iain Hume when Preston visit the Keepmoat Stadium.
Hume is on loan at Rovers from the Lilywhites and as part of the agreement he is unable to face his parent club.
Billy Paynter may replace the Canadian up front.
Paynter returned to the squad against Leyton Orient on Saturday following a thigh injury and played the final few minutes of the 2-0 victory in east London.
Fellow summer signing Robbie Blake is also an option for manager Dean Saunders.
Martin Woods, who was a late substitute against Orient after sustaining an ankle knock during the Capital One Cup defeat at Norwich, and fellow midfielder Paul Keegan will hope to come back into contention for starting roles.
Preston are without the suspended Keith Keane.
The full-back, who returned from injury in the 3-2 victory over Yeovil after missing four games, picked up a fifth yellow card of the season and was hit with a one match ban.
Shane Cansdell-Sherriff is expected to return at centre-back in Keane's absence, with fellow Australian Bailey Wright moving over to full-back.
Manager Graham Westley remains without injured duo Lee Holmes and Lee Trundle. Holmes has a badly gashed leg while Trundle has a knee problem.
But, other than that, Westley has a fully-fit squad at his disposal.
Preston will look to continue their good run of form at the Keepmoat Stadium, where they have not lost since 1994.